Sidelined for five years since they spectacularly rescued New York City from destruction. the superstars of the supernatural spring back into action when the infant son of single mother Dana Barrett becomes the target of a powerful demonic force. Reunited with the no-nonsense Zeddemore, nerdy nearsighted Louis, and their ever-industrious secretary Janine, the heroes of the hereafter must put a stop to an enormous underground river of slime ready to rot the roots of the entire Big Apple. Now, if your hometown was on the verge of being sucked down into the 10th level of Hell, who else would you call?