In Pittsburgh, a woman named Amanda Cooper (Adria Arjona) falls ill with a rare form of cancer. Her husband, the survival expert Ray Cooper (Jason Momoa), is told that a potentially life-saving drug (a generic version of a cancer drug from BioPrime) for Amanda was pulled off the market days before her treatment was set to begin, due to BioPrime CEO Simon Keeley (Justin Bartha) paying the manufacturer to delay production. Watching Keeley on a live debate with Congresswoman Diana Morgan (Amy Brenneman) (Diana was debating against the licensing practices of big Pharma that make drugs very expensive and out of reach for patients), Ray calls in and threatens Keeley, saying if he doesn't reverse his decision, he'll kill him. Keeley doesn't take the threat seriously and Amanda passes away soon after, devastating Ray and their daughter, Rachel (Isabela Merced). Ray was training Rachel as a survival expert and was also teaching her boxing and self-defense.Six months later, Ray receives a call from a journalist, Martin Bennett (Nelson Franklin), who tells him that he has evidence of criminal activity committed by BioPrime. They meet on a subway, unknowingly followed by Rachel and a hit-man named Santos (Manuel Garcia-Rulfo). Bennett explains that BioPrime has been bribing anyone who questions their dirty deeds, but before he can share his information, Santos stabs him dead. As the train stops at a station, Santos stabs Ray and knocks out Rachel, leaving them both on the platform for dead.Two years later, Ray has been obsessively tracking Keeley's movements. Ray poses as a waiter to infiltrate BioPrime's charity auction (To announce the strategic partnership between BioPrime and US Govt for cancer cure drugs, to cap the cost of treatment) so he can interrogate Keeley. Keeley says he knows nothing and tells him to go after BioPrime's chairman, Vinod Shah (Raza Jaffrey) (Keeley says that Vinod hired him, and nothing happens without his explicit sign off). After a brutal fight that leaves one of Keeley's bodyguards dead, Ray strangles Keeley to death with a plastic bag.Ray then gets Rachel, and they hide in a motel outside of town (they leave the US and enter Canada). Rachel, concerned that her father has gone too far, contacts FBI Agent Sarah Meeker (Lex Scott Davis) and tries to convince her to look into BioPrime. The next morning, two mercenaries break into the motel and Ray kills them both, resulting in further tension between him and Rachel. Ray plans to go after Shah and lets Rachel help him trap Shah. Rachel uses a disposable cell phone to keep in touch with Meeker and provide her regular updates on whats happening with them.Ray plans an elaborate plan to separate Vinod from his entourage, while he is driving back home through an abandoned stretch of the woods. Ray succeeds, but Vinod's car is then attacked by Santos. Ray tries to interrogate him (to find out who the bribes were paid to), but Shah refuses to talk and is soon killed by Santos. Ray and Rachel manage to escape, but later meet with Santos in a diner, and after Santos admits that he finds himself sympathetic to Ray's cause, he reveals that Morgan is his real employer (they don't attack each other due to the presence of cops). He also tells Rachel that they will meet again soon.Returning to the city, Ray is ambushed by the FBI (who got reports of a stolen tow truck near where Vinod was killed and tracks it back entering the city) and flees to the roof of a baseball stadium. As Meeker tries to talk him down, it's revealed that "Ray" is actually Rachel. Ray died from his wounds at the subway and Rachel, suffering from PTSD and a fugue state, devoted herself to finishing his quest for vengeance. She jumps into the river but gets knocked unconscious and put in an ambulance. After breaking free and crashing the vehicle, she locates Morgan's campaign office, where Santos is waiting. Despite him initially managing to subdue her by strangling and drowning her, Rachel is able to regain her strength and stabs Santos to death.She confronts Morgan and secretly records her admitting she was bribed by BioPrime for government contracts (she needed the money for her campaign) and that she ordered the hit on Bennett and Ray. After sending the recording to the FBI, Rachel obtains a fake passport, exchanges her money for Cryptocurrency, and boards a plane to an uncertain future.